Merrimack to Present Multiple Posters at the 2012 American Association for Cancer Research Conference "Pancreatic Cancer: Progress and Challenges"
Preclinical data on the mechanism of action of MM-398 in pancreatic cancer will be presented
Preclinical data on MM-398's extended pharmacological profile will be presented
Preclinical data on the pharmaceutical properties and pharmacokinetic profiles of MM-141 will be presented
MM-398
MM-398 is a novel, stable nanotherapeutic encapsulation of the marketed chemotherapy drug irinotecan. MM-398 is designed to deliver a high drug load with high in vivo stability directly to cancer cells. Merrimack is conducting a pivotal Phase 3 clinical trial,
| Synopsis: This translational study shows that MM-398 reduces tumor growth in multiple mouse models of pancreatic cancer. These data support the hypothesis that MM-398's activity may be driven by its ability to impact hypoxic and highly-vascularized tumors. |
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Title: MM-398/PEP02, a novel liposomal formulation of irinotecan demonstrates stromal-modifying anti-cancer properties Session: Poster Session A Abstract Number: A63 Date/Time: June 19, 2012 from Location: |
| Synopsis: A systems pharmacology approach was used to find that liposomal encapsulation of irinotecan dramatically alters the pharmacokinetic profile of SN-38 in tumors and could potentially result in beneficial effects on treatment of pancreatic cancer and other solid tumors. |
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Title: Sustained intratumoral activation of MM-398 results in superior activity over irinotecan demonstrated by using a systems pharmacology approach Session: Poster Session A Abstract Number: A41 Date/Time: Location: |
MM-141
MM-141 is an IGF-1R signaling inhibitor that is designed to address the redundancies that occur in tumors where both IGF-1R and ErbB3 (HER3) are activated, an approach intended to improve patient response by blocking survival signaling promoted by two separate pathways. MM-141 is expected to enter clinical development in the second half of 2012.
| Synopsis: Preclinical studies demonstrate that MM-141 displays activity in pancreatic cancer models and suggest that MM-141 has the potential to be an effective therapeutic for patients with solid tumors including pancreatic cancer. |
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Title: MM-141, a Novel Tetravalent Bispecific Antibody Directed at IGF-1R and ErbB3 that Inhibits Pancreatic Tumor Cell Growth and Potentiates the Effects of Gemcitabine Session: Poster Session A Abstract Number: A38 Date/Time: Location: |
About Merrimack
Merrimack is a biopharmaceutical company discovering, developing and preparing to commercialize innovative medicines paired with companion diagnostics for the treatment of serious diseases, with an initial focus on cancer. Merrimack applies Network Biology, its proprietary systems biology-based approach to biomedical research, throughout the research and development process. Merrimack currently has five targeted therapeutic oncology candidates in clinical development.
Cautionary Note on Forward-Looking Statements
To the extent that statements contained in this press release are not descriptions of historical facts, they are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements include any statements about Merrimack's strategy, future operations, future financial position and future expectations and plans and prospects for Merrimack, and any other statements containing the words "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "predict," "project," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions. In this press release, Merrimack's forward-looking statements include statements about Merrimack's intended poster presentations, the design of Merrimack's
product candidates and the timing of the clinical development of Merrimack's product candidates. Such forward-looking statements involve substantial risks and uncertainties that could cause Merrimack's clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the initiation of future clinical trials, availability of data from ongoing clinical trials, expectations for regulatory approvals, development progress of Merrimack's companion diagnostics, and other matters that could affect the availability or commercial potential of Merrimack's drug candidates or companion diagnostics. Merrimack undertakes no obligation to update or revise any forward-looking statements. Forward-looking statements should not
be relied upon as representing Merrimack's views as of any date subsequent to the date hereof. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Merrimack's business in general, see the "Risk Factors" section of Merrimack's Quarterly Report on Form 10-Q filed with the
CONTACT:Source:Kathleen Petrozzelli Gallagher Corporate Communications, Merrimack 617-441-1043, kgallagher@merrimackpharma.comBetsy Stevenson RaymondStevenson Healthcare Communications 860-984-1424, betsy@raymondstevenson.com
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